Article: Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.
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Masoli S; Solinas S; D'Angelo E
Front Cell Neurosci, 2015
Table 2
Ionic mechanisms in the PC model: I .
Conductance/Location Gmax (S/cm2 ) Erev (mV) Description of channel (H.H or Markovian) References
Na CHANNEL
Nav1.6
Dendrites
0.016
60
Markovian 13 states
Raman and Bean, 2001
Soma
0.214
AIS
0.5
Nodes
0.03
Collateral
0.03
K CHANNELS
Kv1.1
Dendrites
0.0012
-88
HH
Akemann and Knopfel, 2006
Soma
0.002
ParaAIS
0.01
Kv1.5
Dendrites
1.3*10-4
-88
HH
Courtemanche et al., 1998
Kv3.3
Dendrites
0.01
-88
HH
Akemann and Knopfel, 2006
Kv3.4
Soma
0.05
-88
HH
Raman and Bean, 2001 ; Khaliq et al., 2003
AIS
0.01
Nodes
0.01
Collateral
0.02
Kv4.3
Dendrites
0.001
-88
HH
Diwakar et al., 2009
Kir2.x
Dendrites
0.00001
-88
HH
Diwakar et al., 2009
Soma
0.00003
Ca DEPENDENT K CHANNELS
Kca1.1
Dendrites
3.5*10-2
-88
Markovian
Anwar et al., 2010
Soma
0.01
Kca2.2
Dendrites
1*10-3
-88
Markovian
Solinas et al., 2007a ,b
Soma
1*10-3
Kca3.1
Dendrites
0.002
-88
HH
Rubin and Cleland, 2006
Soma
0.01
Ca CHANNELS
Cav2.1
Dendrites
1*10-3
137.5
HH
Swensen and Bean, 2005 ; Anwar et al., 2010
Soma
2.2*10-4
AIS
2.2*10-4
Nodes
2.2*10-4
Collateral
2.2*10-4
Cav3.1
Dendrites
5*10-6
137.5
HH
Anwar et al., 2010
Soma
7*10-6
AIS
1*10-5
Nodes
1*10-5
Collateral
1*10-5
Cav3.2
Dendrites
0.0012
137.5
HH
Huguenard and McCormick, 1992
Soma
0.0008
Cav3.3
Dendrites
0.0001
137.5
HH
Xu and Clancy, 2008
Soma
0.0001
MIXED CATIONIC CHANNEL
HCN1
Dendrites
0.000004
-34.4
HH
Angelo et al., 2007 ; Larkum et al., 2009
Soma
0.0004
CALCIUM BUFFER—PUMPS DENSITY
Ca Buffer
Dendrites
2*10-8
Markovian
Anwar et al., 2010
Soma
5*10-8
AIS
5*10-8
Nodes
5*10-7
Collateral
5*10-8
The table shows ionic channel localization, maximum conductance and reversal potential. Gating equations were written either in Hodgkin-Huxley (HH) style or Markovian style according to indicated references.
Inferred neuron-electrophysiology data values
Neuron Type
Neuron Description
Ephys Prop
Extracted Value
Standardized Value
Content Source
